Archive for the ‘Surgery Notes’ Category.

The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the EnRoute+ Study

Background

The presence of lymph node metastases remains the most reliable prognostic predictor and the gold indicator for adjuvant treatment in colon cancer (CC). In spite of a potentially curative resection, 20 to 30% of CC patients testing negative for lymph node metastases (i.e. pN0) will subsequently develop locoregional and/or systemic metastases within 5 years. The presence of occult nodal isolated tumor cells (ITCs) and/or micrometastases (MMs) at the time of resection predisposes CC patients to high risk for disease recurrence. These pN0micro+ patients harbouring occult micrometastases may benefit from adjuvant treatment.

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Stand-out Science Recognized at Luncheon

2011 Science Day winners were honored at a luncheon on April 6. The winning posters in the pre- and postdoctoral student categories as well as postdoctoral fellow categories were on display. In addition, students who have won other awards for research throughout the year were on hand to display their work and receive recognition from the assembled group of students, staff, and faculty, as well as special guest Provost Karen Antman.

  Associate Dean for Research Maria Kukuruzinska and Dean Jeffrey W. Hutter both addressed the guests and shared how proud they were of all GSDM researchers. Read more…

Prospective study of immunological factors in non-inflammatory bowel disease enterocutaneous fistulas

Background

Enterocutaneous fistulas (ECF) are debilitating and usually result following complex abdominal surgery. While there is an association with inflammatory bowel disease (IBD), a large number of fistulas occur after surgery not related to IBD. The consequences of ECF include short bowel syndrome and the need for long term parenteral nutrition.

ECF can heal spontaneously and in the case of IBD can be cured by medical therapy in some instances. Those that do not resolve spontaneously have to be cured by surgery which is complex and associated with a high morbidity.

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Totally Biological Composite Aortic Stentless Valved Conduit for Aortic Root Replacement: 10-year Experience

To retrospectively analyze the clinical outcome of a totally biological composite stentless aortic valved conduit (No-React(R) BioConduit) implanted using the Bentall procedure over ten years in a single centre.

Between 27/10/99 and 19/01/08, the No-React(R) BioConduit composite graft was implanted in 67 patients. Data on these patients were collected from the in-hospital database, from patient notes and from questionnaires. A cohort of patients had 2D-echocardiogram an average of 4.3+/-0.45 years post-operatively to evaluate valve function, calcification, and the diameter of the conduit.

Implantation in 67 patients represented a follow-up of 371.3 patient-year.

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Na Tian PERIO 14 Debuts New Research to Great Acclaim

Na Tian PERIO 14 recently won second prize for her poster presentation at the Second Annual Translational Research Symposium on May 26. Her poster was titled, “Discovery of Natural Gluten-Degrading Enzymes in the Oral Cavity: Novel Therapeutic Perspectives for Celiac Disease.” Tian has received prior awards for another research poster titled, “Proteolytic Degradation of Immunogenic 33-mer and 26-mer Gliadin-Derived Peptides by Oral Bacteria Reduces Tissue Transglutaminase Recognition In Vitro.” The poster she presented at the Translation Research Symposium was new work, which compared to the last poster was more systemic and comprehensive.   Said Read more…